Neuro News (2)
Depression is a disorder that often comes along with strong impairments of social functioning. Until recently, researchers assumed that acute episodes of depression also impair empathy, an essential skill for successful social interactions and understanding others. However, previous research had been mostly carried out in groups of patients who were on antidepressant medication. Novel insights of an interdisciplinary collaboration involving social neuroscientists, neuroimaging experts, and psychiatrists from the University of Vienna and the Medical University of Vienna show that antidepressant treatment can lead to impaired empathy regarding the perception of pain, and not just the state of depression itself. The results of this study have been published in the scientific journal Translational Psychiatry.
An interdisciplinary research team jointly led by Prof. Claus Lamm (Department of Basic Psychological Research and Research Methods, University of Vienna), Prof. Rupert Lanzenberger (Department of Psychiatry and Psychotherapy, Medical University of Vienna) and Prof. Christian Windischberger (Center for Medical Physics and Bioengineering, Medical University of Vienna) set out to disentangle effects of acute depressive episodes and antidepressant treatment on empathy. The research has been performed within the research cluster "Multimodal Neuroimaging in Clinical Neurosciences", an intramural research initiative aimed at translational collaborations between researchers at the University of Vienna and the Medical University of Vienna. The researchers recruited unmedicated patients with acute depression, and tested their empathic responses to the pain of others twice: first, during an acute depressive episode, i.e., before they had received any medication. Second, after three months of psychopharmacological treatment with antidepressants (mostly selective serotonin reuptake inhibitors).
In both sessions, patients underwent functional magnetic resonance imaging while watching videos of people undergoing painful medical procedures. Their brain activity and self-reported empathy were compared to those of a group of healthy controls. Before treatment, patients and controls responded in a comparable way. After three months of antidepressant treatment, the research revealed relevant differences: patients reported their level of empathy to be lower, and brain activation was reduced in areas previously associated with empathy.
First author Markus Rütgen underlines that reduced empathic responses were not caused by a general dampening of negative emotions: "The lowered emotional impact of negative events in a social context possibly allows patients to recover more easily. Nevertheless, the actual impact of reduced empathy on patients' social behavior remains to be explored."
A multidisciplinary team at Massachusetts General Hospital, including Martinos Center investigators, released to the public today an MRI scan of the human brain at 100 micron resolution. This is the highest resolution MRI scan of the whole human brain to date. The images are 1,000 times more detailed than a standard clinical MRI scan. The brain was donated by a 58-year-old woman who died of non-neurological causes. Her family provided informed consent for the research. The researchers imaged her brain for 5 days continuously on a 7 Tesla MRI scanner using custom-built coil technology. They envision that this ultra-high resolution MRI scan will have a broad range of investigational, educational, and clinical applications that will advance understanding of human brain anatomy in health and disease.
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